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Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis

BACKGROUND: Early death during TB treatment is associated with depressed TNFα response to antigenic stimulation and propensity to superadded bacterial infection. Hypothesising the role of monocyte unresponsiveness, we further compared the immunological profile between patients who died or suffered a...

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Detalhes bibliográficos
Publicado no:BMC Infect Dis
Main Authors: Waitt, Catriona John, Banda, Peter, Glennie, Sarah, Kampmann, Beate, Squire, S. Bertel, Pirmohamed, Munir, Heyderman, Robert Simon
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643523/
https://ncbi.nlm.nih.gov/pubmed/26567164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-015-1274-4
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