Fragile X Mental Retardation Protein Interactions with a G quadruplex structure in the 3′-Untranslated Region of NR2B mRNA

Fragile X syndrome, the most common cause of inherited intellectual disability, is caused by a trinucleotide CGG expansion in the 5′-untranslated region of the FMR1 gene, which leads to the loss of expression of the fragile X mental retardation protein (FMRP). FMRP, an RNA-binding protein that regul...

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發表在:Mol Biosyst
Main Authors: Stefanovic, Snezana, DeMarco, Brett A., Underwood, Ayana, Williams, Kathryn R., Bassell, Gary J., Mihailescu, Mihaela Rita
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643373/
https://ncbi.nlm.nih.gov/pubmed/26412477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5mb00423c
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