ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans

The serine-threonine kinase ataxia-telangiectasia mutated (ATM) plays a central role in maintaining genomic integrity. In mice, ATM deficiency is exclusively associated with T-cell lymphoma development, whereas B-cell tumors predominate in human ataxia-telangiectasia patients. We demonstrate in this...

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Pubblicato in:Blood
Autori principali: Hathcock, Karen S., Padilla-Nash, Hesed M., Camps, Jordi, Shin, Dong-Mi, Triner, Daniel, Shaffer, Arthur L., Maul, Robert W., Steinberg, Seth M., Gearhart, Patricia J., Staudt, Louis M., Morse, Herbert C., Ried, Thomas, Hodes, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643004/
https://ncbi.nlm.nih.gov/pubmed/26400962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-654749
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