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Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly
A recent paper in this journal argued that reported expression levels, k(cat) and K(m) for drug transporters could be used to estimate the likelihood that drug fluxes through Caco-2 cells could be accounted for solely by protein transporters. It was in fact concluded that if five such transporters c...
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| Izdano u: | Trends Pharmacol Sci |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Published By Elsevier In Association With The International Union Of Pharmacology
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4642801/ https://ncbi.nlm.nih.gov/pubmed/26538313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.07.006 |
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