Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients

Pantothenate kinase-associated neurodegeneration is an early onset autosomal recessive movement disorder caused by mutation of the pantothenate kinase-2 gene, which encodes a mitochondrial enzyme involved in coenzyme A synthesis. The disorder is characterised by high iron levels in the brain, althou...

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Bibliographische Detailangaben
Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Santambrogio, Paolo, Dusi, Sabrina, Guaraldo, Michela, Rotundo, Luisa Ida, Broccoli, Vania, Garavaglia, Barbara, Tiranti, Valeria, Levi, Sonia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academic Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642744/
https://ncbi.nlm.nih.gov/pubmed/25836419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.030
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