Mir-21–Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact

Glioblastoma (GBM) is the most aggressive human brain tumor. Although several molecular subtypes of GBM are recognized, a robust molecular prognostic marker has yet to be identified. Here, we report that the stemness regulator Sox2 is a new, clinically important target of microRNA-21 (miR-21) in GBM...

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Publicado no:J Neurosci
Main Authors: Sathyan, Pratheesh, Zinn, Pascal O., Marisetty, Anantha L., Liu, Bin, Kamal, Mohamed Mostafa, Singh, Sanjay K., Bady, Pierre, Lu, Li, Wani, Khalida M., Veo, Bethany L., Gumin, Joy, Kassem, Dina Hamada, Robinson, Frederick, Weng, Connie, Baladandayuthapani, Veerabhadran, Suki, Dima, Colman, Howard, Bhat, Krishna P., Sulman, Erik P., Aldape, Ken, Colen, Rivka R., Verhaak, Roel G.W., Lu, Zhimin, Fuller, Gregory N., Huang, Suyun, Lang, Frederick F., Sawaya, Raymond, Hegi, Monika, Majumder, Sadhan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642241/
https://ncbi.nlm.nih.gov/pubmed/26558781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1265-15.2015
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