Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

Increased dietary consumption of docosahexaenoic acid (DHA) is associated with decreased risk for Alzheimer’s disease (AD). These effects have been postulated to arise from DHA’s pleiotropic effects on AD pathophysiology, including its effects on β-amyloid (Aβ) production, aggregation, and toxicity....

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Udgivet i:Neurobiol Dis
Main Authors: Teng, Edmond, Taylor, Karen, Bilousova, Tina, Weiland, David, Pham, Thaidan, Zuo, Xiaohong, Yang, Fusheng, Chen, Ping-Ping, Glabe, Charles G., Takacs, Alison, Hoffman, Dennis R., Frautschy, Sally A., Cole, Gregory M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641021/
https://ncbi.nlm.nih.gov/pubmed/26369878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.09.002
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