Nitric Oxide Releasing Nanoparticles prevent Propionibacterium acnes induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response

Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 inflammasome was recently highlighted as a dominant etiological factor for acne vulgaris. Therefore, therapeutics targeting both the stimulus and the cascade would be ideal. Nitric oxide (NO), a potent biological messenger, has do...

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Pubblicato in:J Invest Dermatol
Autori principali: Qin, Min, Landriscina, Angelo, Rosen, Jamie, Wei, Gabrielle, Kao, Stephanie, Olcott, William, Agak, George W., Paz, Karin Blecher, Bonventre, Josephine, Clendaniel, Alicea, Harper, Stacey, Adler, Brandon, Krausz, Aimee, Friedman, Joel, Nosanchuk, Joshua, Kim, Jenny, Friedman, Adam J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640998/
https://ncbi.nlm.nih.gov/pubmed/26172313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2015.277
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