Optimizing tamoxifen-inducible Cre/loxp system to reduce tamoxifen effect on bone turnover in long bones of young mice

For tamoxifen-dependent Cre recombinase, also known as CreER recombinase, tamoxifen (TAM) is used to activate the Cre to generate time- and tissue-specific mouse mutants. TAM is a potent CreER system inducer; however, TAM is also an active selective estrogen receptor modulator (SERM) that can influe...

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Udgivet i:Bone
Main Authors: Zhong, Zhendong A., Sun, Weihua, Chen, Haiyan, Zhang, Hongliang, Lay, Yu-an E., Lane, Nancy E., Yao, Wei
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640982/
https://ncbi.nlm.nih.gov/pubmed/26232373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.07.034
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