Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent

Plasmodium falciparum infection can cause microvascular dysfunction, cerebral encephalopathy and death if untreated. We have previously shown that high concentrations of free heme, and C-X-C motif chemokine 10 (CXCL10) in sera of malaria patients induce apoptosis in microvascular endothelial and neu...

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Vydáno v:PLoS One
Hlavní autoři: Dickinson-Copeland, Carmen M., Wilson, Nana O., Liu, Mingli, Driss, Adel, Salifu, Hassana, Adjei, Andrew A., Wilson, Michael, Gyan, Ben, Oduro, Daniel, Badu, Kingsley, Botchway, Felix, Anderson, Winston, Bond, Vincent, Bacanamwo, Methode, Singh, Shailesh, Stiles, Jonathan K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640861/
https://ncbi.nlm.nih.gov/pubmed/26555697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142328
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