Maternal CD4(+) T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission

Elucidation of maternal immune correlates of protection against congenital cytomegalovirus (CMV) is necessary to inform future vaccine design. Here, we present a novel rhesus macaque model of placental rhesus CMV (rhCMV) transmission and use it to dissect determinants of protection against congenita...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bialas, Kristy M., Tanaka, Takayuki, Tran, Dollnovan, Varner, Valerie, Cisneros De La Rosa, Eduardo, Chiuppesi, Flavia, Wussow, Felix, Kattenhorn, Lisa, Macri, Sheila, Kunz, Erika L., Estroff, Judy A., Kirchherr, Jennifer, Yue, Yujuan, Fan, Qihua, Lauck, Michael, O’Connor, David H., Hall, Allison H. S., Xavier, Alvarez, Diamond, Don J., Barry, Peter A., Kaur, Amitinder, Permar, Sallie R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640765/
https://ncbi.nlm.nih.gov/pubmed/26483473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511526112
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