Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens

The activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) relies on chronic active B-cell receptor (BCR) signaling. BCR pathway inhibitors induce remissions in a subset of ABC DLBCL patients. BCR microclusters on the surface of ABC cells resemble those generated following anti...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Young, Ryan M., Wu, Tianyi, Schmitz, Roland, Dawood, Moez, Xiao, Wenming, Phelan, James D., Xu, Weihong, Menard, Laurence, Meffre, Eric, Chan, Wing-Chung C., Jaffe, Elaine S., Gascoyne, Randy D., Campo, Elías, Rosenwald, Andreas, Ott, German, Delabie, Jan, Rimsza, Lisa M., Staudt, Louis M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640740/
https://ncbi.nlm.nih.gov/pubmed/26483459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514944112
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