Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line

We have previously shown that the nuclear receptor, NR1D1, is a cofactor in ApoA-IV-mediated downregulation of gluconeogenesis. Nuclear receptor, NR4A1, is involved in the transcriptional regulation of various genes involved in inflammation, apoptosis, and glucose metabolism. We investigated whether...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Xiaoming, Xu, Min, Wang, Fei, Ji, Yong, DavidsoN, W. Sean, Li, Zongfang, Tso, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640595/
https://ncbi.nlm.nih.gov/pubmed/26556724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142098
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