An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

Reversible epithelial-to-mesenchymal transition (EMT) is central to tissue development, epithelial stemness, and cancer metastasis. While many regulatory elements have been identified to induce EMT, the complex process underlying such cellular plasticity remains poorly understood. Utilizing a system...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Hong, Tian, Watanabe, Kazuhide, Ta, Catherine Ha, Villarreal-Ponce, Alvaro, Nie, Qing, Dai, Xing
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640575/
https://ncbi.nlm.nih.gov/pubmed/26554584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004569
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