Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients

AIM: The present study aimed to evaluate the effects of gene variants in key genes influencing pharmacokinetic and pharmacodynamic of carbamazepine (CBZ) on the response in patients with epilepsy. MATERIALS & METHODS: Five SNPs in two candidate genes influencing CBZ transport and metabolism, nam...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Daci, Armond, Beretta, Giangiacomo, Vllasaliu, Driton, Shala, Aida, Govori, Valbona, Norata, Giuseppe Danilo, Krasniqi, Shaip
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640545/
https://ncbi.nlm.nih.gov/pubmed/26555147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142408
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