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Control of IL-17 receptor signaling and tissue inflammation by the p38α–MKP-1 signaling axis in a mouse model of multiple sclerosis
T helper 17 (T(H)17) cells are CD4(+) T cells that secrete the proinflammatory cytokine interleukin-17 (IL-17) and that play a key pathogenic role in autoimmune diseases. Through inducible and tissue-specific deletion systems, we described the temporal and cell type–specific roles of the mitogen-act...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4640462/ https://ncbi.nlm.nih.gov/pubmed/25737586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa2147 |
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