Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer

BACKGROUND: The enhancer of zeste-homolog 2 (EZH2) is involved in cancer development through gene silencing by trimethylation of lysine 27 of histone 3 (H3K27me3). The C/C genotype for the EZH2 rs3757441 single-nucleotide polymorphism (SNP) is linked with poor prognosis in metastatic colorectal canc...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Fornaro, Lorenzo, Faviana, Pinuccia, De Gregorio, Veronica, Vivaldi, Caterina, Paolicchi, Elisa, Masi, Gianluca, Loupakis, Fotios, Sensi, Elisa, Lupi, Cristiana, Fontanini, Gabriella, Wang, Yuzhuo, Danesi, Romano, Falcone, Alfredo, Crea, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640238/
https://ncbi.nlm.nih.gov/pubmed/26553291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1889-2
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