Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26

BACKGROUND: Recurrence of colorectal cancer (CRC) may arise due to the persistence of drug-resistant and cancer-initiating cells that survive exposure to chemotherapy. Proteins responsible for this recurrence include the chemokine receptor CXCR4, which is known to enable CRC metastasis, as well as t...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Cutler, Murray J., Lowthers, Erica L., Richard, Cynthia L., Hajducek, Dagmar M., Spagnuolo, Paul A., Blay, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640216/
https://ncbi.nlm.nih.gov/pubmed/26552750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1702-2
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