Mucosal-associated invariant T cell–rich congenic mouse strain allows functional evaluation

Mucosal-associated invariant T cells (MAITs) have potent antimicrobial activity and are abundant in humans (5%–10% in blood). Despite strong evolutionary conservation of the invariant TCR-α chain and restricting molecule MR1, this population is rare in laboratory mouse strains (≈0.1% in lymphoid org...

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Pubblicato in:J Clin Invest
Autori principali: Cui, Yue, Franciszkiewicz, Katarzyna, Mburu, Yvonne K., Mondot, Stanislas, Le Bourhis, Lionel, Premel, Virginie, Martin, Emmanuel, Kachaner, Alexandra, Duban, Livine, Ingersoll, Molly A., Rabot, Sylvie, Jaubert, Jean, De Villartay, Jean-Pierre, Soudais, Claire, Lantz, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639991/
https://ncbi.nlm.nih.gov/pubmed/26524590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82424
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