Adaptation of H9N2 AIV in guinea pigs enables efficient transmission by direct contact and inefficient transmission by respiratory droplets

H9N2 avian influenza viruses circulate worldwide in poultry and have sporadically infected humans, raising concern whether H9N2 viruses have pandemic potential. Here, we use a guinea pig model to examine whether serial passage results in adaptive viral changes that confer a transmissible phenotype t...

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Vydáno v:Sci Rep
Hlavní autoři: Sang, Xiaoyu, Wang, Airong, Ding, Jie, Kong, Huihui, Gao, Xiaolong, Li, Lin, Chai, Tongjie, Li, Yuanguo, Zhang, Kun, Wang, Chengyu, Wan, Zhonghai, Huang, Geng, Wang, Tiecheng, Feng, Na, Zheng, Xuexing, Wang, Hualei, Zhao, Yongkun, Yang, Songtao, Qian, Jun, Hu, Guixue, Gao, Yuwei, Xia, Xianzhu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639850/
https://ncbi.nlm.nih.gov/pubmed/26552719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15928
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