Mice lacking the PSD-95–interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning

Protein ubiquitination has a significant influence on diverse aspects of neuronal development and function. Dorfin, also known as Rnf19a, is a RING finger E3 ubiquitin ligase implicated in amyotrophic lateral sclerosis and Parkinson’s disease, but its in vivo functions have not been explored. We rep...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Park, Hanwool, Yang, Jinhee, Kim, Ryunhee, Li, Yan, Lee, Yeunkum, Lee, Chungwoo, Park, Jongil, Lee, Dongmin, Kim, Hyun, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639748/
https://ncbi.nlm.nih.gov/pubmed/26553645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16410
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