Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

Post-transcriptional regulation is an essential determinant of gene expression programs in physiological and pathological conditions. HuR is a RNA-binding protein that orchestrates the stabilization and translation of mRNAs, critical in inflammation and tumor progression, including tumor necrosis fa...

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Pubblicato in:Sci Rep
Autori principali: D’Agostino, Vito Giuseppe, Lal, Preet, Mantelli, Barbara, Tiedje, Christopher, Zucal, Chiara, Thongon, Natthakan, Gaestel, Matthias, Latorre, Elisa, Marinelli, Luciana, Seneci, Pierfausto, Amadio, Marialaura, Provenzani, Alessandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639722/
https://ncbi.nlm.nih.gov/pubmed/26553968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16478
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