Cytotoxicity of the Sesquiterpene Lactones Neoambrosin and Damsin from Ambrosia maritima Against Multidrug-Resistant Cancer Cells

Multidrug resistance is a prevailing phenomenon leading to chemotherapy treatment failure in cancer patients. In the current study two known cytotoxic pseudoguaianolide sesquiterpene lactones; neoambrosin (1) and damsin (2) that circumvent MDR were identified. The two cytotoxic compounds were isolat...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Saeed, Mohamed, Jacob, Stefan, Sandjo, Louis P., Sugimoto, Yoshikazu, Khalid, Hassan E., Opatz, Till, Thines, Eckhard, Efferth, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637410/
https://ncbi.nlm.nih.gov/pubmed/26617519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00267
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