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Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

Recent work has shown that the ability of cytokines to direct immunoglobulin heavy chain class-switch recombination to particular heavy chain constant (C) region (CH) genes correlates with the induction of specific germ-line CH transcripts. To test the role of germ-line transcripts in class switchin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Xu, L, Gorham, B, Li, S C, Bottaro, A, Alt, F W, Rothman, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46370/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8475119/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3705
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