Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis

In the intestinal tract, IL-22 activates STAT3 to promote intestinal epithelial cell (IEC) homeostasis and tissue healing. The mechanism has remained obscure, but we demonstrate that IL-22 acts via tyrosine kinase 2 (Tyk2), a member of the Jak family. Using a mouse model for colitis, we show that Ty...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Hainzl, Eva, Stockinger, Silvia, Rauch, Isabella, Heider, Susanne, Berry, David, Lassnig, Caroline, Schwab, Clarissa, Rosebrock, Felix, Milinovich, Gabriel, Schlederer, Michaela, Wagner, Michael, Schleper, Christa, Loy, Alexander, Urich, Tim, Kenner, Lukas, Han, Xiaonan, Decker, Thomas, Strobl, Birgit, Müller, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
Assuntos:
Mucosal Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635564/
https://ncbi.nlm.nih.gov/pubmed/26432894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402565
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