Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse

BACKGROUND: For clinical translation, we assessed whether intranasal mesenchymal stem cell (MSC) treatment after hypoxia–ischemia (HI) induces neoplasia in the brain or periphery at 14 mo. Furthermore, the long-term effects of MSCs on behavior and lesion size were determined. METHOD: HI was induced...

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Detalhes bibliográficos
Publicado no:Pediatr Res
Main Authors: Donega, Vanessa, Nijboer, Cora H., van Velthoven, Cindy T. J., Youssef, Sameh A., de Bruin, Alain, van Bel, Frank, Kavelaars, Annemieke, Heijnen, Cobi J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Basic Science Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635434/
https://ncbi.nlm.nih.gov/pubmed/26270577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2015.145
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