Ketamine attenuates the Na(+)-dependent Ca(2+) overload in rabbit ventricular myocytes in vitro by inhibiting late Na(+) and L-type Ca(2+) currents

AIM: Intracellular Ca(2+) ([Ca(2+)](i)) overload occurs in myocardial ischemia. An increase in the late sodium current (I(NaL)) causes intracellular Na(+) overload and subsequently [Ca(2+)](i) overload via the reverse-mode sodium-calcium exchanger (NCX). Thus, inhibition of INaL is a potential thera...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Luo, An-tao, Cao, Zhen-zhen, Xiang, Yu, Zhang, Shuo, Qian, Chun-ping, Fu, Chen, Zhang, Pei-hua, Ma, Ji-hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635330/
https://ncbi.nlm.nih.gov/pubmed/26456586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.75
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