A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State

Predisposition to breast and extrauterine Müllerian carcinomas in BRCA1 mutation carriers is due to a combination of cell-autonomous consequences of BRCA1 inactivation on cell cycle homeostasis superimposed on cell-nonautonomous hormonal factors magnified by the effects of BRCA1 mutations on hormona...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Liu, Ying, Yen, Hai-Yun, Austria, Theresa, Pettersson, Jonas, Peti-Peterdi, Janos, Maxson, Robert, Widschwendter, Martin, Dubeau, Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634618/
https://ncbi.nlm.nih.gov/pubmed/26629527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.08.034
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