Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy

Muscle weakness and exercise intolerance are hallmark symptoms in mitochondrial disorders. Little is known about the mechanisms leading to impaired skeletal muscle function and ultimately muscle weakness in these patients. In a mouse model of lethal mitochondrial myopathy, the muscle-specific Tfam k...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Principais autores: Gineste, Charlotte, Hernandez, Andres, Ivarsson, Niklas, Cheng, Arthur J., Naess, Karin, Wibom, Rolf, Lesko, Nicole, Bruhn, Helene, Wedell, Anna, Freyer, Christoph, Zhang, Shi-Jin, Carlström, Mattias, Lanner, Johanna T., Andersson, Daniel C., Bruton, Joseph D., Wredenberg, Anna, Westerblad, Håkan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634369/
https://ncbi.nlm.nih.gov/pubmed/26374844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv361
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