Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells

BACKGROUND: The chemokine CCL20 and its receptor CCR6 are putative drug targets in inflammatory bowel disease, and CCL20 is a novel IBD predilection gene. Previous findings on the CCL20 response in these diseases are divergent. This study was undertaken to examine CCL20 and CCR6 during active and in...

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Pubblicato in:PLoS One
Autori principali: Skovdahl, Helene Kolstad, Granlund, Atle van Beelen, Østvik, Ann Elisabet, Bruland, Torunn, Bakke, Ingunn, Torp, Sverre Helge, Damås, Jan Kristian, Sandvik, Arne Kristian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633243/
https://ncbi.nlm.nih.gov/pubmed/26536229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141710
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