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A Large-Scale Analysis of the Relationship of Synonymous SNPs Changing MicroRNA Regulation with Functionality and Disease

Historically, owing to not changing amino acid composition of protein sequences, synonymous mutations are commonly assumed to be neutral during evolution and therefore have no effect on the phenotype and disease. Here, based on observations from large-scale analysis of genomic data, we predicted the...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Wang, Yuchen, Qiu, Chengxiang, Cui, Qinghua
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632712/
https://ncbi.nlm.nih.gov/pubmed/26437399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms161023545
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