Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

Tissue-type plasminogen activator (tPA) is a pleiotropic serine protease of the central nervous system (CNS) with reported neurotrophic and neurotoxic functions. Produced and released under its single chain form (sc), the sc-tPA can be cleaved by plasmin or kallikrein in a two chain form, tc-tPA. Al...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Bertrand, T, Lesept, F, Chevilley, A, Lenoir, S, Aimable, M, Briens, A, Hommet, Y, Bardou, I, Parcq, J, Vivien, D
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632317/
https://ncbi.nlm.nih.gov/pubmed/26469972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.296
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