Pur-alpha functionally interacts with FUS carrying ALS-associated mutations

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to motor neuron loss. Fused in sarcoma (FUS) protein carrying ALS-associated mutations localizes to stress granules and causes their coalescence into larger aggregates. Here we show that Pur-alpha physically interacts with...

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Publicat a:Cell Death Dis
Autors principals: Di Salvio, M, Piccinni, V, Gerbino, V, Mantoni, F, Camerini, S, Lenzi, J, Rosa, A, Chellini, L, Loreni, F, Carrì, M T, Bozzoni, I, Cozzolino, M, Cestra, G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632316/
https://ncbi.nlm.nih.gov/pubmed/26492376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.295
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