Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task

The locus coeruleus (LC) is the sole source of noradrenergic projections to the cortex and essential for attention-dependent cognitive processes. In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC on prefron...

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Detalhes bibliográficos
Publicado no:Front Behav Neurosci
Main Authors: Janitzky, Kathrin, Lippert, Michael T., Engelhorn, Achim, Tegtmeier, Jennifer, Goldschmidt, Jürgen, Heinze, Hans-Jochen, Ohl, Frank W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631833/
https://ncbi.nlm.nih.gov/pubmed/26582980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00286
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