Metabolic Coupling Determines the Activity: Comparison of 11β-Hydroxysteroid Dehydrogenase 1 and Its Coupling between Liver Parenchymal Cells and Testicular Leydig Cells

BACKGROUND: 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) interconverts active 11β-hydroxyl glucocorticoids and inactive 11keto forms. However, its directionality is determined by availability of NADP+/NADPH. In liver cells, 11β-HSD1 behaves as a primary reductase, while in Leydig cells it acts as a...

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Veröffentlicht in:PLoS One
Hauptverfasser: Li, Xingwang, Hu, Guoxin, Li, Xiaoheng, Wang, Yi-Yan, Hu, Yuan-Yuan, Zhou, Hongyu, Latif, Syed A., Morris, David J., Chu, Yanhui, Zheng, Zhiqiang, Ge, Ren-Shan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631333/
https://ncbi.nlm.nih.gov/pubmed/26528718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141767
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