Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4

A series of combretastatin A-4 (CA-4) analogues have been prepared from (Z)-substituted diarylacrylonitriles (1a–1p) obtained in a two-step synthesis from appropriate arylaldehydes and acrylonitriles. The resulting 4,5-disubstituted 2H-1,2,3-triazoles were evaluated for their anti-cancer activities...

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Bibliographic Details
Published in:Eur J Med Chem
Main Authors: Madadi, Nikhil R., Penthala, Narsimha R., Howk, Kevin, Ketkar, Amit, Eoff, Robert L., Borrelli, Michael J., Crooks, Peter A.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631050/
https://ncbi.nlm.nih.gov/pubmed/26352674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.08.041
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