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Assessment of the predictive accuracy of five in silico prediction tools, alone or in combination, and two metaservers to classify long QT syndrome gene mutations

BACKGROUND: Long QT syndrome (LQTS) is an autosomal dominant condition predisposing to sudden death from malignant arrhythmia. Genetic testing identifies many missense single nucleotide variants of uncertain pathogenicity. Establishing genetic pathogenicity is an essential prerequisite to family cas...

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Publié dans:BMC Med Genet
Auteurs principaux: Leong, Ivone US, Stuckey, Alexander, Lai, Daniel, Skinner, Jonathan R, Love, Donald R
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630850/
https://ncbi.nlm.nih.gov/pubmed/25967940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-015-0176-z
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