In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.

The cytotoxic neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal (ALLN) inhibits cell-cycle progression in CHO cells, affecting the G1/S and metaphase-anaphase transition points, as well as S phase. Mitotic arrest induced by ALLN is associated with the inhibition of cyclin B degrada...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Sherwood, S W, Kung, A L, Roitelman, J, Simoni, R D, Schimke, R T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46298/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386372/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3353
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