Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization.
Cyclophilin is a binding protein for the immunosuppressive drug cyclosporin A and is also an enzyme with peptidyl-prolyl cis-trans isomerase activity. The crystal structure of cyclophilin A complexed with the substrate Ala-Pro has been determined and refined to an R factor of 0.196 at 1.64-A resolut...
Збережено в:
| Опубліковано в:: | Proc Natl Acad Sci U S A |
|---|---|
| Автори: | , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
National Academy of Sciences
1993
|
| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46292/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8475075/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3324 |
| Теги: |
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|