A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

Recognition and elimination of tumor cells by the immune system is crucial for limiting tumor growth. Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on cancer cell lines. However, the molecular mechanisms...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gowen, Benjamin G, Chim, Bryan, Marceau, Caleb D, Greene, Trever T, Burr, Patrick, Gonzalez, Jeanmarie R, Hesser, Charles R, Dietzen, Peter A, Russell, Teal, Iannello, Alexandre, Coscoy, Laurent, Sentman, Charles L, Carette, Jan E, Muljo, Stefan A, Raulet, David H
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629278/
https://ncbi.nlm.nih.gov/pubmed/26565589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08474
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