Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy

The diet-induced obesity (DIO) model is frequently used to examine the pathogenesis of obesity-related pathologies; however, only minimal glomerulosclerosis (GS) has been reported after 3 mo. We investigated if GS develops over longer periods of DIO and examined the potential role of hemodynamic mec...

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Polichnowski, Aaron J., Licea-Vargas, Hector, Picken, Maria, Long, Jianrui, Bisla, Rashmi, Williamson, Geoffrey A., Bidani, Anil K., Griffin, Karen A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628946/
https://ncbi.nlm.nih.gov/pubmed/26109088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00211.2015
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