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Competition of two distinct actin networks for actin defines a bistable switch for cell polarization

Symmetry-breaking polarization enables functional plasticity of cells and tissues and is yet not well understood. Here we show that epithelial cells, hard-wired to maintain a static morphology and to preserve tissue organization, can spontaneously switch to a migratory polarized phenotype upon relax...

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Bibliografiska uppgifter
I publikationen:Nat Cell Biol
Huvudupphovsmän: Lomakin, Alexis J., Lee, Kun-Chun, Han, Sangyoon J., Bui, D A., Davidson, Michael, Mogilner, Alex, Danuser, Gaudenz
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628555/
https://ncbi.nlm.nih.gov/pubmed/26414403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3246
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