Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer’s disease

Alzheimer’s disease (AD), the most common form of dementia, disproportionately affects women in both prevalence and severity. This increased vulnerability to AD in women is strongly associated with age-related ovarian hormone loss and apolipoprotein E 4 allele (ApoE4), the most important genetic ris...

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Gepubliceerd in:Front Aging Neurosci
Hoofdauteurs: Hou, Xu, Adeosun, Samuel O., Zhang, Qinli, Barlow, Brett, Brents, Melissa, Zheng, Baoying, Wang, Junming
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2015
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628114/
https://ncbi.nlm.nih.gov/pubmed/26582141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2015.00207
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