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Blood-Derived CD4 T Cells Naturally Resist Pyroptosis During Abortive HIV-1 Infection
Progression to AIDS is driven by CD4 T-cell depletion, mostly involving pyroptosis elicited by abortive HIV infection of CD4 T cells in lymphoid tissues. Inefficient reverse transcription in these cells leads to cytoplasmic accumulation of viral DNAs that are detected by the DNA sensor IFI16, result...
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| Udgivet i: | Cell Host Microbe |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627664/ https://ncbi.nlm.nih.gov/pubmed/26468749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.09.010 |
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