Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation

This paper focuses on the retrospective evaluation of physiologically based pharmacokinetic (PBPK) techniques used to mechanistically predict clearance throughout pediatric life. An intravenous tramadol retrograde PBPK model was set up in Simcyp® using adult clearance values, qualified for CYP2D6, C...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: T’jollyn, Huybrecht, Snoeys, Jan, Vermeulen, An, Michelet, Robin, Cuyckens, Filip, Mannens, Geert, Van Peer, Achiel, Annaert, Pieter, Allegaert, Karel, Van Bocxlaer, Jan, Boussery, Koen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627449/
https://ncbi.nlm.nih.gov/pubmed/26209290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9803-z
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