RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates

APOBEC3G (A3G) DNA deaminase activity requires a holoenzyme complex whose assembly on nascent viral reverse transcripts initiates with A3G dimers binding to ssDNA followed by formation of higher-order A3G homo oligomers. Catalytic activity is inhibited when A3G binds to RNA. Our prior studies sugges...

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Publicado en:Nucleic Acids Res
Autores principales: Polevoda, Bogdan, McDougall, William M., Tun, Bradley N., Cheung, Michael, Salter, Jason D., Friedman, Alan E., Smith, Harold C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627094/
https://ncbi.nlm.nih.gov/pubmed/26424853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv970
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