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Phosphorylation of NR2B NMDA subunits by protein kinase C in arcuate nucleus contributes to inflammatory pain in rats

The arcuate nucleus (ARC) of the hypothalamus plays a key role in pain processing. Although it is well known that inhibition of NMDA receptor (NMDAR) in ARC attenuates hyperalgesia induced by peripheral inflammation, the underlying mechanism of NMDAR activation in ARC remains unclear. Protein kinase...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bu, Fan, Tian, Huiyu, Gong, Shan, Zhu, Qi, Xu, Guang-Yin, Tao, Jin, Jiang, Xinghong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626761/
https://ncbi.nlm.nih.gov/pubmed/26515544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15945
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