Spiromastixones Inhibit Foam Cell Formation via Regulation of Cholesterol Efflux and Uptake in RAW264.7 Macrophages

Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of a culture broth resulted in the isolation of 15 known depsidone-based analogues, labeled spiromastixones A–O (1–15). Each of these compounds...

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Detalhes bibliográficos
Publicado no:Mar Drugs
Main Authors: Wu, Chongming, Chen, Ran, Liu, Mingyue, Liu, Dong, Li, Xin, Wang, Shuai, Niu, Siwen, Guo, Peng, Lin, Wenhan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626694/
https://ncbi.nlm.nih.gov/pubmed/26473890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13106352
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