Partitioning heritability by functional annotation using genome-wide association summary statistics

Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here, we analyze a broad set of functional elements, including cell-type-specific elements, to estimate their polygenic contributions to heritability in g...

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Pubblicato in:Nat Genet
Autori principali: Finucane, Hilary K., Bulik-Sullivan, Brendan, Gusev, Alexander, Trynka, Gosia, Reshef, Yakir, Loh, Po-Ru, Anttila, Verneri, Xu, Han, Zang, Chongzhi, Farh, Kyle, Ripke, Stephan, Day, Felix R., Consortium, ReproGen, Purcell, Shaun, Stahl, Eli, Lindstrom, Sara, Perry, John R. B., Okada, Yukinori, Raychaudhuri, Soumya, Daly, Mark, Patterson, Nick, Neale, Benjamin M., Price, Alkes L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626285/
https://ncbi.nlm.nih.gov/pubmed/26414678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3404
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