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Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease
INTRODUCTION: Alzheimer’s disease (AD), characterized by the accumulation of hyperphosphorylated tau and beta amyloid (Aβ), currently lacks effective treatment. Chaperone proteins, such as the heat shock protein (Hsp) 90, form macromolecular complexes with co-chaperones, which can regulate tau metab...
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| 發表在: | Expert Opin Ther Targets |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4625388/ https://ncbi.nlm.nih.gov/pubmed/25069659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2014.943185 |
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